Molecular Bottlebrushes for Immunostimulatory CpG ODN Delivery: Relationship among Cation Density, Complex Formation Ability, and Cytotoxicity

     

Shin Takano, Yusuke Miyashima, Shota Fujii, Kazuo Sakurai

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Biomacromolecules

Enhanced Therapeutic Efficacy of Immunostimulatory CpG-ODN by Silencing SOCS-1 with Polysaccharide/miR-155 Complexes

     

Kazuki Sumiya, Hiroto Izumi, Kazuo Sakurai

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ACS Applied Bio Materials

Binding assay of human Dectin-1 variants for DNA/β-glucan complex for active-targeting delivery of antisense DNA: Part II

     

Kazuki Sumiya, Hiroto Izumi, Yoshiyuki Adachi, Shinichi Mochizuki, Kazuo Sakurai

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Carbohydrate Research

Protective effects of alpha-mangostin encapsulated in cyclodextrin-nanoparticle on cerebral ischemia

     

Natsumi Oka, Hirofumi Matsubara, Takahiko Imai, Yukie Yoshioka, Jun Katsuki, Shota Fujii, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara, Kazuo Sakurai

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Journal of Controlled Release

Antisense DNA cocktail therapy using short ß-1,3-glucan/oligonucleotide complexes

     

Yuki Hata, Kazuki Sumiya, Hiroto Izumi, Kazuo Sakurai

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Polymer Journal (2022)

Crosslinked Structure of Polyacrylic Acid Affects Pulmonary Fibrogenicity in Rats

     

Taisuke Tomonaga, Chinatsu Nishida, Hiroto Izumi, Naoki Kawai,

 Ke-Yong Wang, Hidenori Higashi, Jun-Ichi Takeshita, Ryohei Ono, Kazuki Sumiya, Shota Fujii, Yuki Hata, Kazuo Sakurai, Toshiki Morimoto, Yasuyuki Higashi, Kei Yamasaki, Kazuhiro Yatera, Yasuo Morimoto

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International Journal of Molecular Sciences

Effect of Different Molecular Weights of Polyacrylic Acid on Rat Lung Following Intratracheal Instillation

     

Chinatsu Nishida, Hiroto Izumi, Taisuke Tomonaga, Ke-Yong Wang, Hidenori Higashi, Jun-Ichi Takeshita, Ryohei Ono, Kazuki Sumiya, Shota Fujii, Yuki Hata, Kazuo Sakurai, Yasuyuki Higashi, Kei Yamasaki, Kazuhiro Yatera, Yasuo Morimoto

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International Journal of Molecular Sciences

Zwitterionic Amino Acid Polymer-Grafted Core-Crosslinked Particle toward Tumor Delivery

     

Shota Fujii, Kazuo Sakurai

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Biomacromolecules

Impact of Polyethylene Glycol (PEG) Conformations on the In Vivo Fate and Drug Release Behavior of PEGylated Core-Cross-Linked Polymeric Nanoparticles

     

Takuma Kanamaru, Kazuo Sakurai, Shota Fujii

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Biomacromolecules

Inflammogenic effect of polyacrylic acid in rat lung following intratracheal instillation

     

Chinatsu Nishida, Taisuke Tomonaga, Hiroto Izumi, Ke-Yong Wang, Hidenori Higashi, Toru Ishidao, Jun-ichi Takeshita, Ryohei Ono, Kazuki Sumiya, Shota Fujii, Shinichi Mochizuki, Kazuo Sakurai, Kei Yamasaki, Kazuhiro Yatera, Yasuo Morimoto

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Particle and Fibre Toxicology 19 (1), 1-17

Impact of Zwitterionic Polymers on the Tumor Permeability of Molecular Bottlebrush-Based Nanoparticles

     

Shota Fujii, Shin Takano, Kohji Nakazawa, Kazuo Sakurai

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Biomacromolecules

Delivery of therapeutic oligonucleotides targeting Dectin-1 using quantized complexes

     

Kazuki Sumiya, Hiroto Izumi, Takuya Matsunaga, Motoko Tanaka, Kazuo Sakurai

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Polymer Journal 54 (4), 591-601

Dramatically Increased Binding Constant of Water-Soluble Cyclodextrin Hyperbranched Polymers: Explored with Diffusion Ordered NMR Spectroscopy (DOSY)

     

Anh Thi Ngoc Doan, Van Thi Hong Doan, Jun Katsuki, Shota Fujii, Hiroyuki Kono, Kazuo Sakurai

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ACS omega 7 (13), 10890-10900

Oligonucleotide delivery to antigen presenting cells by using schizophyllan

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S Mochizuki, N Miyamoto, K Sakurai

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Drug Metabolism and Pharmacokinetics 42, 100434