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  • Oligo-DNA Stoichiometrically Binds β-1, 3-Glucan with the Best Fit Length  Kazuki Sumiya, Takuya Matsunaga, Motoko Tanaka, Shinichi Mochizuki, Kazuo Sakurai  Biomacromolecules

  • Induction of Potent Cell Growth Inhibition by Schizophyllan/K-Ras Antisense Complex in Combination with Gemcitabine  S Sasaki, H Izumi, Y Morimoto, K Sakurai, S Mochizuki  Bioorganic & Medicinal Chemistry, 115668

  • Characterizing an siRNA-Containing Lipid-Nanoparticle Prepared by a Microfluidic Reactor: Small-Angle X-ray Scattering and Cryotransmission Electron Microscopic Studies  Kenichi Aburai, Kentaro Hatanaka, Shin Takano, Shota Fujii, Kazuo Sakurai  Langmuir

  • Scattering Form Factor of Block Copolymer Micelles with Corona Chains Discretely Distributed on the Core Surface  R Takahashi, S Fujii, I Akiba, K Sakurai  The Journal of Physical Chemistry B

  • Synthesis and characterization of nanoemulsion-mediated core crosslinked nanoparticles, and in vivo pharmacokinetics depending on the structural characteristics  J Matsuno, T Kanamaru, K Arai, R Tanaka, JH Lee, R Takahashi,  Journal of Controlled Release

  • Structural Polymorphism of Resorcinarene Assemblies  S Fujii, R Miyake, L Campo, JH Lee, R Takahashi, K Sakurai  Langmuir

  • Cyclodextrin-based nanoparticles encapsulating α-mangostin and their drug release behavior: potential carriers of α-mangostin for cancer therapy  VTH Doan, JH Lee, R Takahashi, PTM Nguyen, TN Van Anh, HTT Pham, ...  Polymer Journal 52 (4), 457-466

  • Topical Therapy with Antisense Tumor Necrosis Factor Alpha Using Novel β-Glucan-Based Drug Delivery System Ameliorates Intestinal Inflammation  H Sakisaka, H Takedatsu, K Mitsuyama, S Mochizuki, K Sakurai, ...  International Journal of Molecular Sciences 21 (2), 683

  • Unraveling the kinetics of the structural development during polymerization-induced self-assembly: decoupling the polymerization and the micelle structure  R Takahashi, S Miwa, FH Sobotta, JH Lee, S Fujii, N Ohta, JC Brendel, ...  Polymer Chemistry 11 (8), 1514-1524

  • Unraveling Decisive Structural Parameters for the Self-Assembly of Supramolecular Polymer Bottlebrushes Based on Benzene Trisureas  FV Gruschwitz, MC Fu, T Klein, R Takahashi, T Higashihara,   Macromolecules

  • Monodisperse Micelles with Aggregation Numbers Related to Platonic Solids  JH Lee, S Fujii, R Takahashi, K Sakurai  Macromolecular Rapid Communications, 2000227

  • Furry nanoparticles: synthesis and characterization of nanoemulsion-mediated core crosslinked nanoparticles and their robust stability in vivo  R Tanaka, K Arai, J Matsuno, M Soejima, JH Lee, R Takahashi, K Sakurai, ...  Polymer Chemistry 11 (27), 4408-4416

  • Enhanced Binding Constant of Cyclodextrin to Alpha-mangostin in Hyperbranched Polymers  DTH Van, DTN Anh, S Fujii, K Sakurai  Chemistry Letters 49 (X)

  • Flower Necklaces of Controllable Length Formed From N-(2-Hydroxypropyl) Methacrylamide-Based Amphiphilic Statistical Copolymers  R Takahashi, K Doi, S Fujii, K Sakurai  Langmuir


  • Non-dependence of dodecamer structures on alkyl chain length in Platonic micelles  Masataka Araki, Shota Fujii,  Ji Ha Lee, Rintaro Takahashi and Kazuo Sakurai  Article in Soft Matter  in press

  • Dual and Multiple Stimuli-Responsive Platonic Micelles Bearing Disaccharides  Rika Miyake,Shota Fujii,JI Ha Lee,Rintaro Takahashi,Kazuo Sakurai  Article in Journal of Colloid and Interface Science volume 535 Pages 8-15

  • A Discrete and Discontinuous Increase in the Micellar Aggregation Number: Effects of the Alkyl Chain Length on Platonic Micelles  Shota Fujii,Shimpei Yamada,Masataka Araki,Ji Ha Lee,Rintaro Takahashi,Kazuo Sakurai  Langmuir, 2019, 35 (8), pp 3156–3161

  • Tuning of the aggregation number of Platonic micelles with binary mixture of calix[4]arene surfactants  Ji Ha Lee,Shota Fujii,Rintaro Takahashi,Kazuo Sakurai  Article in Chemical Communications 55(9)  

  • Monodisperse micelles composed of poly(ethylene glycol) attached surfactants: platonic nature in a macromolecular aggregate  Ji Ha Lee, Hayata Matsumoto, Shota Fujii, Rintaro Takahashi and Kazuo Sakurai  Article in Soft Matter, 2019

  • Encapsulation of Albumin in Organic Nanotube Channel: Structural Investigation by Small-Angle X-ray Scattering  Hiroki Kawauchi, Rintaro Takahashi, Naohiro Kameta, Shota fujii, Ji Ha Lee, Toshimi Shimizu and Kazuo Sakurai  Article in ACS Appl. Bio Mater. 2019, 2, 4, 1652-1659

  • Observing the Kinetic Pathway of Nanotube Formation from Bolaamphiphiles by Time-Resolved Small-Angle X-ray Scattering  Rintaro Takahashi, Hiroki Kawauchi, Naohiro Kameta, Ji Ha Lee, Shota Fujii, Toshimi Shimizu and Kazuo Sakurai  Article in J. Phys. Chem. B, 2019, 123, 19, 4340-4345

  • Complex consisting of antisense DNA and β-glucan promotes internalization into cell through Dectin-1 and hybridizes with target mRNA in cytosol  Nobuaki Fujiwara, Hiroto Izumi, Yasuo Morimoto, Kazuo Sakurai and Shinichi Mochizuki  Article in Cancer Gene Therapy 26, 32–40 (2019)

  • Co-administration of combretastatin A4 nanoparticles and sorafenib for systemic therapy of hepatocellular carcinoma  Yalin Wang, Haiyang Yu, Dawei Zhang, Guanyi Wang, Wantong Song, Yingmin Liu, Sheng Ma, Zhaohui Tang, Ziling Liu, Kazuo Sakurai and Xuesi Chen  Article in Acta Biomaterialia Vol 92 Pages 229-240

  • Structural analysis of a calix[4]arene-based Platonic Micelle  Efsta Mylonas, Naoto Yagi, Shota Fujii, Koudai Ikesue, Tomoya Ueda, Hideaki Moriyama, Yusuke Sanada, Kazuya Uezu, Kazuo Sakurai and Tadashi Okobira  Article in Scientific Reports 9 Article number 1982 (2019)


  • Highly ordered polypeptide with UCST phase-separation behavior

S Kuroyanagi, N Shimada, S Fujii, T Furuta, A Harada, K Sakurai, K Sakurai,A Maruyama

J. Am. Chem. Soc. 2019, 141, 1261−1268

  • Corrigendum to" Designing an immunocyte-targeting delivery system by use of beta-glucan"[Vaccine 36  (2018) 186-189].

N Miyamoto, S Mochizuki, K Kobiyama, KJ Ishii, K Sakurai

Vaccine 36 (45), 6892

  • Morphological Transition of Oppositely Charged Calix [4] arene Surfactant Mixture

JH Lee, S Fujii, R Takahashi, K Sakurai

Langmuir 34 (40), 12109-12115

  • Core–Shell–Corona Micelles from a Polyether-Based Triblock Terpolymer: Investigation of the pH-ependent Micellar Structure

Shotaro Miwa, Rintaro Takahashi, Carsten Rössel, Sakiko Matsumoto, Shota Fujii, Ji Ha Lee, Felix H. Schacher, Kazuo Sakurai

Langmuir 34 (26), 7813-7820


  • Rediscovering the Monodispersity of Sulfonatocalix [4] arene-Based Micelles

S Fujii, JH Lee, R Takahashi, K Sakurai

Langmuir 34 (17), 5072-5078


  • A tetramer micelle: the smallest aggregation number corresponding to the vertex number ofregularpolyhedra in platonic micelles

S Fujii, R Takahashi, LJ Ha, K Sakurai

Soft matter 14 (6), 875-878


  • Designing an immunocyte-targeting delivery system by use of beta-glucan

N Miyamoto, S Mochizuki, K Sakurai

Vaccine 36 (1), 186-189


  • Elongation induced β- to α-crystalline transformation and microvoid

formation in isotactic polypropylene as revealed by time-resolved WAXS/SAXS

Hideo Kurihara,Shinich Kitade,Kazuyuki Ichino,Isamu Akiba,Kazuo Sakurai

Polymer journal 51,199-209


  • Cross-sectional structures of a molecular monolayer nanotube explored with SAXS: Evidence for the parallel orientation of the headgroups in asymmetric bolaamphiphiles

Kenta Yoshida, Rintaro Takahashi, Shota Fujii,Naohiro Kameta,Toshimi Shimizu and Kazuo Sakurai

Article in Physical Chemistry Chemical Physics 19(36) · August 2017



  • A two-component micelle with emergent pH responsiveness by mixing dilauroyl phosphocholine and deoxycholic acid and its delivery of proteins into the cytosol.

Miyamoto N, Fujii S, Mochizuki S, Sakurai K, Sakaguchi N, Koiwai K.

Article in Colloids and surfaces B: Biointerfaces 154 · March 2017  


  • Self-Assembly of Calix[4]arene-Based Amphiphiles Bearing Polyethylene Glycols: Another Example of “Platonic Micelles”

Kenta Yoshida, Shota Fujii, Rintaro Takahashi , Sakiko Matsumoto, Kazuo Sakurai

Langmuir, 2017, 33 (36), pp 9122–9128    

  • Dynamic Viscoelastic Properties of Poly(Ethylene-Propylene) Diblock Copolymer in the Melt State and Solutions

William MacKnight, K. Sakurai, D.J. Lohse, D.N. Schulz, J.A. Sissano, W. Wedler, H. H. Winter

ELSEVIER November 1996


  • Monitoring the Discontinuous Dodecamer–Icosamer Transition of a Calix[4]arene‐Derived Surfactant by Time‐Resolved Small‐Angle X‐ray Scattering

Rintaro Takahashi, Sakiko Matsumoto, Shota Fujii, Theyencheri Narayanan,  Kazuo Sakurai

Ange Wandte 8 May 2017  

        DOI: 10.1002/ange.201702260           


  • Glutamic Acids Bearing Calix[4]arene Micelles: pH-Controllable Aggregation Number Corresponding to Regular Polyhedra

       Shota Fujii,Rintaro Takahashi,Kazuo Sakurai

       Langmuir, 2017, 33 (16), pp 4019–4027

       DOI: 10.1021/acs.langmuir.7b00603


  • Magnetic metal-complex-conducting copolymer core–shell nanoassemblies for a

single-drug anticancer platform Jeong-Hwan Kim, Haruki Eguchi, Masanari Umemura, Itaru Sato, Shigeki Yamada, Yujiro Hoshino, Takatsugu Masuda, Ichio Aoki, Kazuo Sakurai, Masahiro Yamamoto and Yoshihiro Ishikawa

        PG Asia Materials (2017) 9, e367



  • Ultraviolet Patterned Calixarene-Derived Supramolecular Gels and Films with

Spatially Resolved Mechanical and Fluorescent Properties

Ji Ha Lee , Sung Ho Jung, Shim Sung Lee , Ki-Young Kwon, Kazuo Sakurai, Justyn Jaworski, and Jong Hwa Jung,

ACS Nano, 2017, 11 (4), pp 4155–4164

DOI: 10.1021/acsnano.7b00997

  • Platonic Micelles: Mono disperse Micelles with Discrete Aggregation Numbers Corresponding to Regular Polyhedra

Shota Fujii, Shimpei Yamada, Sakiko Matsumoto, Genki Kubo, Kenta Yoshida, Eri Tabata, Rika Miyake, Yusuke Sanada, Isamu Akiba, Tadashi Okobira, Naoto Yagi, Efstratios Mylonas, Noboru Ohta, Hiroshi Sekiguchi, and Kazuo Sakurai.Scientific Reports (2017) 7:44494


  • Adjuvant activity enhanced by crosslinked CpG-oligonucleotides in beta-glucan nanogel and its anti-tumor effect.

Miyamoto, N.; Mochizuki, S.; Fujii, S.; Yoshida, K.; Sakurai, K., Bioconjugate Chemistry (2016). 28, (2), 565–573,  


  • Oriented crystallization of long chain branched polypropylene induced by step-shear deformation in pre-crystallization regime.

Kitade, S.; Kurihara, H.; Asuka, K.; Katsuno, S.; Akiba, I.; Sakurai, K., Polymer (2017). Volume 116, 5 May 2017, Pages 395–402



  • Chiral Supramolecular Gels with Lanthanide Ions: Correlation between Luminescence and Helical Pitch.

Kim, C.; Kim, K. Y.; Lee, J. H.; Ahn, J.; Sakurai, K.; Lee, S. S.; Jung, J. H., ACS Applied Materials & Interfaces (2017), 9 (4), pp 3799–3807


  • Salt-Induced Morphology Transition of Micelles Formed of Calix[4]arene-Derivative Cationic Surfactants in Aqueous Solution.Matsumoto, Sakiko; Takahashi, Rintaro; Yamada, Shimpei; Fujii, Shota ; Sakurai, Kazuo., Chemistry Letters., Accepted.

  • Concentration-dependent Aggregation Behavior of Asymmetric Cationic Surfactant Hexyldimethyloctylammonium Bromide

author: Anita Hyde, Shota Fujii, Kazuo Sakurai, Chi Phan, and Shin-ichi Yusa (2017),Vol.46, NO.2



  • Supramolecular Chirality: Vesicle-to-Chiral Helix Transition of the Micelles Consisting of a Sugar-Bearing Calix[4]arene Surfactant.

Sakamoto, S.; Fujii, S.; Yoshida, K.; Sakurai, K., Langumuir 2016, 32 (47), pp 12434–12441




  • Water-soluble complex formation of fullerenes with a biocompatible polymer.

Ohata, T.; Ishihara, K.; Iwasaki, Y.; Sangsuwan, A.; Fujii, S.; Sakurai, K.; Ohara, Y.; Yusa, S., Polymer Journal 2016.



  • Micelle formation and red-light fluorescence emission of benzothiazole-triphenylamine amphiphilic molecules in water/methanol solutions explored with synchrotron small-angle X-ray scattering.

Yamada, S.; Sanada, Y; Fujii, S; Kitahara, I.; Akiba, I.; Ishii, T.; Sakurai, K., Polymer Journal 2016.



  • Gene silencing using a conjugate comprising Tat peptide and antisense oligonucleotide with phosphorothioate backbones.

Maegawa, Y.; Mochizuki, S.; Miyamoto, N.; Sakurai, K., Bioorganic & Medicinal Chemistry Letters 2016.


  • Polypod-Shaped DNAs: Small-Angle X-ray Scattering and Immunostimulatory Activity.

Sanada, Y.; Shiomi, T.; Okobira, T.; Tan, M.; Nishikawa, M.; Akiba, I.; Takakura, Y.; Sakurai, K., Langmuir 2016, 32 (15), 3760-3765.


  • Optimal sequence of antisense DNA to silence YB-1 in lung cancer by use of a novel polysaccharide drug delivery system.

Izumi, H.; Nagao, S.; Mochizuki, S.; Fujiwara, N.; Sakurai, K.; Morimoto, Y., International Journal of Oncology 2016, 48 (6), 2472-2478.



  • Competition of PEG Coverage Density and Con-A Recognition in Mannose/PEG Bearing Nanoparticles.

Fukuda, I.; Mochizuki, S.; Sakurai, K., Colloids and Surfaces B: Biointerfaces 2016.


  • Anomalous small-angle X-ray scattering study on the spatial distribution of hydrophobic molecules in polymer micelles.

Nakanishi, R., Machida, G., Kinoshita, M., Sakurai, K., & Akiba, I., Polymer Journal (2016) 48, 801-806 (July 2016)



  • Exploring the relationship between anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance. Shiraishi, K., Kawano, K., Maitani, Y., Aoshi, T., Ishii, K. J., Sanada, Y., Yokoyama, M. J Control Release(2016), 234, 59-67.



  • Amphiphilic benzothiadiazole–triphenylamine-based aggregates that emit red light in water. Ishi-i, T.; Kitahara, I.; Yamada, S.; Sanada, Y.; Sakurai, K.; Tanaka, A.; Hasebe, N.; Yoshihara, T.; Tobita, S., Organic & biomolecular chemistry 2015. 2015,13, 1818-1828. DOI: 10.1039


  • The transfection efficiency of calix [4] arene-based lipids: the role of the alkyl chain length. Mochizuki, S.; Nishina, K.; Fujii, S.; Sakurai, K., Biomater. Sci. 2015, 3 (2), 317-322.


  • Permanent acceptance of mouse cardiac allografts with CD40 siRNA to induce regulatory myeloid cells by use of a novel polysaccharide siRNA delivery system. Zhang, Q.; Ichimaru, N.; Higuchi, S.; Cai, S.; Hou, J.; Fujino, M.; Nonomura, N.; Kobayashi, M.; Ando, H.; Uno, A., Gene therapy 2015.


  • Development of Nonaggregating Poly-A Tailed Immunostimulatory A/D Type CpG Oligodeoxynucleotides Applicable for Clinical Use. Aoshi, T.; Haseda, Y.; Kobiyama, K.; Narita, H.; Sato, H.; Nankai, H.; Mochizuki, S.; Sakurai, K.; Katakai, Y.; Yasutomi, Y., Journal of immunology research 2015.


  • Macrophage-targeting gene delivery using a micelle composed of mannose-modified lipid with triazole ring and dioleoyl trimethylammonium propane. Fukuda, I.; Mochizuki, S.; Sakurai, K., BioMed research international 2015.


  • Rod-like architecture and cross-sectional structure of an amyloid protofilament-like peptide supermolecule in aqueous solution. Minami, T.; Matsumoto, S.; Sanada, Y.; Waku, T.; Tanaka, N.; Sakurai, K., Polymer Journal 2015.


  • Immunization with antigenic peptides complexed with β-glucan induces potent cytotoxic T-lymphocyte activity in combination with CpG-ODNs. Mochizuki, S.; Morishita, H.; Kobiyama, K.; Aoshi, T.; Ishii, K. J.; Sakurai, K., Journal of Controlled Release 2015, 220, 495-502.


  • Synchronized Self-assembly of Fullerene Derivatives Passing Through Programmable Microflow Field. Numata, M.; Kozawa, T.; Nakadozono, T.; Sanada, Y.; Sakurai, K., Chemistry Letters 2015,  (0).


  • Synchronized Activation of π-Conjugated Molecules toward Self-Assembly: Precise Controlling the Hysteresis of the Metastable State along Microflow. Numata, M.; Kozawa, T.; Nogami, R.; Tanaka, K.; Sanada, Y.; Sakurai, K., Bulletin of the Chemical Society of Japan 2015,  (0).


  • Creation of Kinetically Stabilized Porphyrin Microfilms through Synchronized Hydrogen-bonding Interactions in Microflow. Numata, M.; Nishino, Y.; Sanada, Y.; Sakurai, K., Chemistry Letters 2015, 44 (6), 861-863.


  • Determination of polymeric micelles' structural characteristics, and effect of the characteristics on pharmacokinetic behaviors. Shiraishi, K.; Sanada, Y.; Mochizuki, S.; Kawano, K.; Maitani, Y.; Sakurai, K.; Yokoyama, M., Journal of Controlled Release 2015, 203, 77-84.


  • Chain architecture and flexibility of α-cyclodextrin/PEG polyrotaxanes in dilute solutions. Yamada, S.; Sanada, Y.; Tamura, A.; Yui, N.; Sakurai, K., Polymer Journal 2015, 47 (6), 464-467.


  • Prevention of copper-induced cell death by GC-rich DNA oligomers in murine macrophage-like RAW264. 7 cells. Matsushita, S.; Mochizuki, S.; Sakurai, K.; Kawano, T., Communicative & Integrative Biology 2015,  (just-accepted), 00-00.


  • Micelles consisting of choline phosphate-bearing Calix [4] arene lipids. Fujii, S.; Nishina, K.; Yamada, S.;  Mochizuki, S.; Ohta, N.; Takahara, A.; Sakurai, K., Soft matter 2014, 10 (41), 8216-8223.


  • Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist. Kobiyama, K.; Aoshi, T.; Narita, H.; Kuroda, E.; Hayashi, M.; Tetsutani, K.; Koyama, S.; Mochizuki, S.; Sakurai, K.; Katakai, Y., Nonagonistic Proceedings of the National Academy of Sciences 2014, 111 (8), 3086-3091.


  • Transformation from Multi to Single Lamellar Vesicle by Addition of a Cationic Lipid to DLPC Explored with SAXS and TEM.Kubo, G.; Sakamoto, S.; Fujii, S.; Sanada, Y.; Yasunaga, T.; Takahara, A.; Sakurai, K., 2014. Chemistry Letters,Vol. 43 (2014) No. 11 P 1785-1787


  • Naphthalene-hydrophobized β-1, 3-glucan nanogel for doxorubicin delivery to immunocytes Maeda, K.; Mochizuki, S.; Sanada, Y.; Sakurai, K., Bioorganic & medicinal chemistry letters 2014, 24 (8), 1880-1883.


  • Enhanced Immunostimulation with Crosslinked CpG-DNA/beta-1, 3-Glucan Nanoparticle through Hybridization.;Miyamoto, N.; Mochizuki, S.; Sakurai, K., 2014. Chemistry Letters 43 (7), 991-993


  • Binding assay between murine Dectin-1 and β-glucan/DNA complex with quartz-crystal microbalance. Mochizuki, S.; Morishita, H.; Adachi, Y.; Yamaguchi, Y.; Sakurai, K., Carbohydrate research 2014, 391, 1-8.


  • Chain-length dependence of polyion complex architecture bearing phosphobetaine block explored using SAXS and FFF-MALS. Sakamoto, S.; Sanada, Y.; Sakashita, M.; Nishina, K.; Nakai, K.; Yusa, S.-i.; Sakurai, K.,. Polymer Journal 2014. 46, 617-622; doi:10.1038


  • Hepatocyte-targeting gene delivery using a lipoplex composed of galactose-modified aromatic lipid synthesized with click chemistry. Sakashita, M.; Mochizuki, S.; Sakurai, K., Bioorganic & medicinal chemistry 2014, 22 (19), 5212-5219.


  • X-ray Scattering from Immunostimulatory Tetrapod-Shaped DNA in Aqueous Solution To Explore Its Biological Activity–Conformation Relationship. Sanada, Y.; Sakamoto, S.; Shiomi, T.; Okobira, T.; Mylonas, E.; Ohta, N.; Yagi, N.; Nishikawa, M.; Akiba, I.; Takakura, Y., The Journal of Physical Chemistry B 2014, 118 (35), 10373-10379.


  • Advanced Soft Material Beamline Consortium at SPring-8 (FSBL). Takahara, A.; Takeda, T.; Kanaya, T.; Kido, N.; Sakurai, K.; Masunaga, H.; Ogawa, H.; Takata, M., Synchrotron Radiation News 2014, 27 (3), 19-23.


  • The dectin 1 agonist curdlan regulates osteoclastogenesis by inhibiting nuclear factor of activated T cells cytoplasmic 1 (NFATc1) through Syk kinase. Yamasaki, T.; Ariyoshi, W.; Okinaga, T.; Adachi, Y.; Hosokawa, R.; Mochizuki, S.; Sakurai, K.; Nishihara, T., Journal of Biological Chemistry 2014, 289 (27), 19191-19203.


  • The role of the helper lipid dioleoylphosphatidylethanolamine (DOPE) for DNA transfection cooperating with a cationic lipid bearing ethylenediamine.  Mochizuki S, Kanegae N, Nishina K, Kamikawa Y, Koiwai K, Masunaga H, Sakurai K.  Biochim. Biophys. Acta.1828(2), 412-418 (2013). 10.1016/j.bbamem.2012.10.017


  • A simple visual sensor with the potential for determining the concentration of fluoride in water at environmentally significant levels. Tomoki Nishimura ,  Su-Ying Xu ,  Yun-Bao Jiang ,  John S. Fossey ,  Kazuo Sakurai ,  Steven D. Bull and Tony D. James. Chemical Communications, 2013,49, 478-480 DOI: 10.1039/C2CC36107H


  • Hydrophobic Molecules Infiltrating into the Poly(ethylene glycol) Domain of the Core/Shell Interface of a Polymeric Micelle: Evidence Obtained with Anomalous Small-Angle X-ray Scattering. Yusuke Sanada, Isamu Akiba, Kazuo Sakurai, Kouichi Shiraishi, Masayuki Yokoyama, Efstratios Mylonas, Noboru Ohta, Naoto Yagi, Yuya Shinohara , and Yoshiyuki Amemiya. Journal of the American Chemical Society. Publication Date (Web): January 31, 2013 DOI: 10.1021/ja308965j


  • A bimolecular micelle constructed from amphiphilic pillar[5]arene molecules. Tomoki Nishimura , Yusuke Sanada , Takuma Matsuo ,  Tadashi Okobira , Efstratios Mylonas , Naoto Yagi and Kazuo Sakurai. Chem. Commun., 2013, 49, 3052-3054 DOI: 10.1039/C3CC41186A


  • Structural Transition of Lipopolysaccharide and Reduction in the Biological Activity by Amphiphilic Lipid with Cationic Amino Acid.  Li, Wenjing; Mochizuki, Shinichi; Sakurai, Kazuo. Bull. Chem. Soc. Jpn. in press


  • 糖アルコールを有するカチオン性ミセルのpH応答性による構造転移. 松尾拓馬、藤井翔太、眞田雄介、櫻井和朗. 高分子論文集 in press


  • Macrophage specific delivery of TNF- siRNA complexed with -1,3-glucan inhibits LPS-induced cytokine production in a murine acute hepatitis model Bioorganic & Medicinal Chemistry. In press Structural Transition of Lipopolysaccharide and Reduction in the Biological Activity by Amphiphilic Lipid with Cationic Amino Acid.  Li, Wenjing; Mochizuki, Shinichi; Sakurai, Kazuo. Bull. Chem. Soc. Jpn. Vol. 86(2013)No.5, P651-656. 


  • Structural Analysis of a Polymeric Micelle Made from AB3-type Multiarmed Star-like Block Copolymer in an Aqueous Solution. Sanada, Yusuke; Sakamoto, Shunsuke; Akiba, Isamu; Takaki, Toshihiko; Sakurai, Kazuo. Chemistry Letters. Vol.42 No.8 2013 p.882–884 August 5, 2013 doi:10.1246/cl.130285


  • Synthesis and Characterization of a Calix[4]arene Amphiphilie Bearing Cysteine and Uniform Au Nanoparticle Formation Templated by its Four Cysteine Moieties. Fujii, Shota; Sakurai, Kazuo; Okobira, Tadashi; Ohta, Noboru; Takahara, Atsushi. Langmuir. Vol.29 No.45 p.13666-13675 (2013). doi: 10.1021/la403377a.


  • Preparation and Characterization of Polyion Complex Micelles with Phosphobetaine Shells. Nakai K, Nishiuchi M, Inoue M, Ishihara K, Sanada Y, Sakurai K, Yusa S. Langmuir. Vol.29 No.31 p.9651-9661 (2013). doi: 10.1021/la401063b


  • Menthol-enhanced Cytotoxicity of Cigarette Smoke Demonstrated in Two Bioassay Models. Noriyasu A, Konishi T, Mochizuki S, Sakurai K, Tanaike Y, Matsuyama K, Uezu T, Kawano T. Tob. Induc. Dis. Vol. 11 No.1 p.18-22 (2013). doi: 10.1186/1617-9625-11-18.


  • Crystallization kinetics of polypropylene containing a sorbitol nucleating agent. Katsuno, Satoshi; Yoshinaga, Masahiro; Kitade, Shinichi; Sanada, Yusuke; Akiba, Isamu; Sakurai, Kazuo, Masunaga, Hiroyasu; Polym J., Vol. 45 No.1 p. 87-93(2013). doi: 10.1038/pj.2012.199


  • Shear-induced pre-crystallization structures of long chain branched polypropylene under steady shear flow near the melting temperature, Kitade, Shinichi; Asuka, Kazuo; Akiba, Isamu; Sanada, Yusuke; Sakurai, Kazuo; Masunaga, Hiroyasu, Polymer, Vol. 54 No.1 p. 246-257 (2013). Doi: 10.1016/j.polymer.2012.10.048


  • Accurate measurements of intrinsic scattering from window materials by use of a vacuum camera, H. Masunaga, K. Sakurai, I. Akiba, K. Ito and M. Takata, J. Appl. Cryst., Vol. 46 p. 577-579 (2013).   doi:10.1107/S0021889813002628


  • Study of the internal structure of polymer micelles by anomalous small-angle X-ray scattering at two edges, M. Sakou, A. Takechi, S. Murakami, K. Sakurai and I. Akiba, J. Appl. Cryst., Vol. 46, p. 1407-1413 (2013). doi:10.1107/S0021889813022450


  • Pyrene-anchored boronic acid receptors on carbon nanoparticle supports: fluxionality and pore effects, Katherine Lawrence, Tomoki Nishimura, Peter Haffenden, John M. Mitchels, Kazuo Sakurai, John S. Fossey, Steven D. Bull, Tony D. Jamesa and Frank Marken, New J. Chem., Vol. 37 p. 1883-1888 (2013). doi: 10.1039/C3NJ00017F


  • A Stimulus-Responsive Shape-Persistent Micelle Bearing a Calix[4]arene Building Block: Reversible pH-Dependent Transition between Spherical and Cylindrical Forms. Shota Fujii, Yusuke Sanada, Tomoki Nishimura, Isamu Akiba, and Kazuo Sakurai , Naoto Yagi and Efstratios Mylonas. Langmuir, 2012, 28 (6), pp 3092–3101, DOI: 10.1021/la2037668

  • β-1,3-d-Glucan Schizophyllan/Poly(dA) Triple-Helical Complex in Dilute Solution. Yusuke Sanada, Tsubasa Matsuzaki, Shinichi Mochizuki, Tadashi Okobira, Kazuya Uezu, and Kazuo Sakurai. J. Phys. Chem. B, 2012, 116 (1), pp 87–94, DOI: 10.1021/jp209027u

  • A New Therapeutic Approach Using a Schizophyllan-based Drug Delivery System for Inflammatory Bowel Disease. Hidetoshi Takedatsu, Keiichi Mitsuyama, Shinichi Mochizuki, Teppei Kobayashi, Kazuo Sakurai, Hiroshi Takeda, Yoshihide Fujiyama, Yoshikazu Koyama, Jun Nishihira and Michio Sata. Molecular Therapy , 20, 1234-1241 (June 2012) doi:10.1038/mt.2012.24

  • Rapid separation of proteins from the aqueous media using the novel gelation protocol. Takashi Kadono, Yasuaki Fukuta, Kazuya Uezu, Hiroshi Morita, Kazuo Sakurai, and Tomonori Kawano. Current Topics in Peptide & Protein Research.


  • Modeling and Evaluation of a Twist Drive Actuator for Soft Robotics. Ivan Godler , Takashi Sonoda and Kazuo Sakurai. Advanced Robotics 26 (2012) 765–783. DOI:10.1163/156855312X626307

  • Relationship between DNA-Transfection Efficiency and Chemical Structures of Aromatic Cationic Lipids. Shinichi Mochizuki, Yumi Kamikawa, Koichi Nishina, Shota Fujii, Emi Hamada, Shota Kusuki, Takuma Matsuo, and Kazuo Sakurai. Bull. Chem. Soc. Jpn. Vol. 85, No. 3, 354-359(2012), DOI: 10.1246/bcsj.20110296


  • Thermodynamics of Lipoplex Formation: Relationship between the Lipid Alkyl Tail Length and Thermodynamic Functions. Shota Fujii, Tomoki Nishimura, and Kazuo Sakurai. Chem. Lett. Vol.41, No.5, pp.501--503, (2012)

  • Anomalous Small-Angle X-ray Scattering Study of Structure of Polymer Micelles Having Bromines in Hydrophobic Core. Isamu Akiba, Atsuro Takechi, Megumi Sakou, Masashi Handa, Yuya Shinohara, Yoshiyuki Amemiya, Naoto Yagi, and Kazuo Sakurai. Macromolecules, (Web): July 23, 2012 (Article) DOI: 10.1021/ma300461d.

  • Composition Dependence of the Micellar Architecture Made from Poly(ethylene glycol)-block-Poly(partially benzyl-esterified aspartic acid). Yusuke Sanada, Isamu Akiba, Satoshi Hashida, and Kazuo Sakurai , Kouichi Shiraishi and Masayuki Yokoyama , Naoto Yagi , Yuya Shinohara and Yoshiyuki Amemiya. J. Phys. Chem. B, (2012), 116 (28), pp 8241–8250. DOI: 10.1021/jp300936d

  • 多糖β-1,3-グルカンの受容体を利用したオリゴ核酸の選択的デリバリー 宮本 寛子, 望月慎一, 櫻井 和朗Cellulose communications 19(1), 12-16, 2012


  • SAXSとFFF-MALSを組合せた高分子ミセルのキャラクタリゼーション. 真田 雄介, 秋葉 勇, 橋田智史, 白石 貢一, 横山 昌幸, 八木 直人, 篠原 裕也, 雨宮慶幸, 櫻井 和朗. 高分子論文集 Vol. 69 (2012) No. 7 p. 346-357


  • カチオン性脂質ミセルと DNA が形成する複合体の超分子構造 —構造のDNA 鎖長と塩基種依存性—. 飯野智絵, 櫻木美菜, 増永啓康, 櫻井和朗.  高分子論文集 Vol. 69 (2012) No. 2 , P 84-88

  • Dependence of the swelling of a pH-responsive PEG-modified nanogel on the cross-link density. G. Tamura, Y. Shinohara, A. Tamura, Y. Sanada, M. Oishi, I. Akiba, Y. Nagasaki, K. Sakurai, and Y. Amemiya, Polymer Journal, 44, 240-244 (2012)

  • The role of the helper lipid dioleoylphosphatidylethanolamine (DOPE) for DNA transfection cooperating with a cationic lipid bearing ethylenediamine. Mochizuki, S.; Kanegae, N.; Nishina, K.; Kamikawa, Y.; Koiwai, K.; Masunaga, H.; Sakurai, K. Biochimica et Biophysica Acta (BBA) – Biomembranes (2012) web

  • Shear-induced pre-crystallization structures of long chain branched polypropylene under steady shear flow near the melting temperature.

       Kitade, S.; Asuka, K.; Akiba, I.; Sanada, Y.; Sakurai, K.; Masunaga, H. Polymer (2012) web

  • ssDNA–dsRNAs are cleaved at the next to its chimera-junction point by an unknown RNase activity. Mochizuki, S.; Higuchi, S.; Sakurai, K. Biochemical and Biophysical Research Communications (2012) web

  • Crystallization kinetics of polypropylene containing a sorbitol nucleating agent. Satoshi Katsuno, Masahiro Yoshinaga, Shinichi Kitade, Yusuke Sanada, Isamu Akiba, Kazuo Sakurai and Hiroyasu Masunaga. Polymer Journal , (14 November 2012)  doi:10.1038/pj.2012.199 web

  • Exploiting the Reversible Covalent Bonding of Boronic Acids: Recognition, Sensing, and Assembly. Steven D Bull, Matthew G. Davidson, Jean M. H. van den Elsen, John S. Fossey , A. Toby A. Jenkins, Yun-Bao Jiang , Yuji Kubo , Frank Marken, Kazuo Sakurai, Jianzhang Zhao , and Tony D. James. Accounts of chemical research. Publication Date (Web): November 14, 2012  DOI: 10.1021/ar300130w

  • A simple visual sensor with the potential for determining the concentration of fluoride in water at environmentally significant levels. Tomoki Nishimura, Su-Ying Xu, Yun-Bao Jiang, Kazuo Sakurai, Steven D. Bull, and Tony D. James. ChemComm. Nov 12, 2012 accepted


  • Transformation from Multilamellar to Unilamellar Vesicles by Addition of a Cationic Lipid to PEGylated Liposomes Explored with Synchrotron Small Angle X-ray Scattering. Sakuragi, M.; Koiwai, K.; Nakamura, K.; Masunaga, H.; Ogawa, H.; Sakurai, K. In, Journal of Physics. 272(2011),  doi:10.1088/1742-6596/272/1/012011

  • Dectin-1 targeting delivery of TNF-a antisense ODNs complexed with b-1,3-glucan protects mice from LPS-induced hepatitis. Shinichi Mochizuki, and Kazuo Sakurai. Journal of Controlled Release. Volume 151, Issue 2, 30 April 2011, 155-161

  • Enhanced Cytokine Secretion from Primary Macrophages due to Dectin-1 Mediated Uptake of CpG DNA/β-1,3-glucan Complex. Minari, Jusaku; Mochizuki, Shinichi; Matsuzaki, Tsubasa; Adachi, Yoshiyuki; Ohno, Naohito; Sakurai, Kazuo. Bioconjugate Chemistry  22 p9-15, DOI: 10.1021/bc1001196

  • Thermosensitive Molecular Assemblies from Poly(amidoamine)Dendron-Based Lipids. Kenji Kono, Etsuo Murakami, Yuki Hiranaka, Eiji Yuba, Chie Kojima, Atsushi Harada, and Kazuo Sakurai. A journal of the Gesellschaft Deutscher Chemiker Angewandte Chemie 2011 50/28 p6332-6336  DOI:10.1002/anie.201101007

  • Multipurpose soft-material SAXS/WAXS/GISAXS beamline at SPring-8. Hiroyasu Masunaga, Hiroki Ogawa, Takumi Takano, Sono Sasaki, Shunji Goto, Takashi Tanaka, Takamitsu Seike, Sunao Takahashi, Kunikazu Takeshita, Nobuteru Nariyama, Haruhiko Ohashi, Toru Ohata, Yukito Furukawa, Tomohiro Matsushita, Yasuhide Ishizawa, Naoto Yagi, Masaki Takata, Hideo Kitamura, Kazuo Sakurai, Kohji Tashiro, Atsushi Takahara, Yoshiyuki Amamiya, Kazuyuki Horie, Mikihito Takenaka, Toshiji Kanaya, Hiroshi Jinnai, Hiroshi Okuda, Isamu Akiba, Isao Takahashi, Katsuhiro Yamamoto, Masamichi Hikosaka, Shinichi Sakurai, Yuya Shinohara, Akihiko Okada and Yasunori Sugihara. Polymer Journal.(2011)43, 471-477

  • Quaternary-ammonium-bearing Aromatic Surfactants: Effect of the Alkyl Chain Positions on Their Micelle and DNA-complex Structures. Takuma Matsuo, Shota Fujii, Yumi Kamikawa, Tomoki Nishimura, Yusuke Sanada, Shinichi Mochizuki and Kazuo Sakurai. Chemistry Letters . Vol. 40 (2011) , No. 12 p.1340-1342. doi:10.1246/cl.2011.1340 

  • Metal-ion induced transition from multi-to single-bilayer tubes in histidine bearing lipids and formation of monodisperse Au nanoparticles. Tomoki Nishimura, Takuma Matsuo and Kazuo Sakurai. Physical Chemistry Chemical Physics. 2011, 13, 15899-15905  DOI: 10.1039/C1CP21065C

  • Increased Cellular Transfection with Magnetized DNA/Benzyl Amine Lipid Complexes. Mina Sakuragi, Shinichi Mochizuki and Kazuo Sakurai. Bulletin of the Chemical Society Japan. Vol.84, No.8, 2011 P839-844, August 15.

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